Wednesday, July 22, 2020

GPR 55



G protein-coupled receptor 55 also known as GPR55 is a G protein-coupled receptor that in humans is encoded by the GPR55 gene.[5]
GPR55, along with GPR119 and GPR18, have been implicated as novel cannabinoid receptors.[6][7]

History[edit]

GPR55 was identified and cloned for the first time in 1999.[8] Later it was identified by an in silico screen as a putative cannabinoid receptor because of a similar amino acid sequence in the binding region.[9] Research groups from Glaxo Smith Kline and Astra Zeneca characterized the receptor extensively because it was hoped to be responsible for the blood pressure lowering properties of cannabinoids. GPR55 is indeed activated by endogenous and exogenous cannabinoids such as plant and synthetic cannabinoids but GPR-55 knockout mice generated by a research group from Glaxo Smith Kline showed no altered blood pressure regulation after administration of the cannabidiol-derivative abnormal cannabidiol.[10]

Signal cascade[edit]

GPR55 is coupled to the G-protein G13 and activation of the receptor leads to stimulation of rhoAcdc42 and rac1.[11]

Pharmacology[edit]

GPR55 is activated by the plant cannabinoids Δ9-THC[12] and the endocannabinoids anandamide2-AG and noladin ether in the low nanomolar range. Exocannabinoids such as the synthetic cannabinoid CP-55940 are also able to activate the receptor[12] while the structurally unrelated cannabinoid mimic WIN 55,212-2 fails to activate the receptor.[10] Recent research suggests that lysophosphatidylinositol and its 2-arachidonoyl derivative, 2-arachidonoyl lysophosphatidylinositol (2-ALPI), may be the endogenous ligands for GPR55[13][14][15] and the receptor appears likely to be a possible target for treatment of inflammation and pain as with the other cannabinoid receptors.[16][17]
This profile as a distinct non-CB1/CB2 receptor which responds to a variety of both endogenous and exogenous cannabinoid ligands has led some groups to suggest GPR55 should be categorised as the CB3 receptor, and this re-classification may follow in time.[18][19][20][21] However this is complicated by the fact that another possible CB3 receptor has been discovered in the hippocampus, although its gene has not yet been cloned,[22] suggesting that there may be at least four cannabinoid receptors which will eventually be characterised. Evidence accumulated during the last few years suggests that GPR55 plays a relevant role in cancer and opens the possibility of considering this orphan receptor as a new therapeutic target and potential biomarker in oncology.[2

Monday, May 20, 2019

CORRUPTION AT THE FDA AND PHARMACEUTICAL INDUSTRY


This is very important to know, read and pass on. 

The pharmaceutical industry is a far more criminal enterprise than you realize.

Consider the following: 90% of the drug supply is generic. 40% of all drugs are manufactured in India. 80% of all active ingredients in our meds are manufactured outside of the U.S. Fraudulent data is being used to certify drugs with the FDA by foreign manufactures.

When U.S. inspectors find discrepancies, the FDA works against its own inspectors, under the Trump administration. 

Drugs are manufactured for the U.S. and Europe under a different standard. Countries in Africa and Asia for example, with lax inspection forces are considered ROW or Rest of the World by drug manufacturers.

Glass and metal fragments are being found in these drugs. People are dying in these countries and if you are traveling abroad, you could be exposed to the impurities.
Doctors, investigative reporters and industry experts are demanding congress investigate. 

Contact your congressional representatives and demand an investigation of the FDA and the pharmaceutical industry.

FDA agents are being poisoned when they visit overseas plans and their hotel rooms are being bugged, yet, the FDA takes the side of the overseas industries instead of THEIR OWN AGENTS! 

See the story of Peter Baker an investigator who was poisoned and threatened for finding impurities in drugs manufactured in India.

FDA inspections are being announced before they take place to give manufacturers time to destroy records and manufacture others. 

Our drugs are constantly being changed (I have noticed this at the VA). To protect ourselves, we must Google FDA warning labels whenever we notice a change in our drugs.

PLEASE WATCH THIS VIDEO BELOW AND SHARE THIS POSTING!



Saturday, February 3, 2018

Monday, December 12, 2016

Al Sanchez of Poly MVA on the Optimal Health Hour Radio Show


The Fight Against Cancer: Intravenous High Dose Vitamin C And Poly-MVA Are Powerful Weapons Used To Fight Everything From Viruses To Cancer Tumor Cells
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The Optimal Health Hour

Tuesday at 2 PM Pacific

November 29, 2016: The Fight Against Cancer: Intravenous High Dose Vitamin C And Poly-MVA Are Powerful Weapons Used To Fight Everything From Viruses To Cancer Tumor Cells
This week’s episode will focus on intravenous High Dose Vitamin C which is considered a "Pro-Oxidant". It is used to fight bacteria, viruses and abnormal cells in the body such as cancer tumor cells. We will also learn about a powerful and revolutionary supplement called Poly-MVA. We will talk with patients and find out how these “super compounds” changed their life. There is a revolution in health care coming, please join us to find out more. Don’t miss out! Be with us for the next Optimal Health Hour episode.
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Featured Guests

Al Sanchez, Jr., CEO AMARC Enterprises

Al Sanchez, Jr. CEO AMARC Enterprises is a member of the Foundation for Advancement in Cancer Research. He speaks at health conferences throughout the world where he shares his research and experience about degenerative diseases. He is also the president of Poly-MVA which provided a unique nutracuitcal that is used at many integrative clinics for people dealing with cancer and other chronic diseases. After losing both his mother, Julia, and sister, Tina, to colon cancer, he committed to joining family, friends and colleagues in their quest to find better options, access to information, treatments, and hopefully one day a cure for those stricken with such a devastating disease. He is d.....
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Dr. Hadas Hilewitz, N.D.

Dr. Hadas Hilewitz started out her career in the conventional medical field, attaining a Master’s degree in Biological Sciences, and then proceeding to work in various fields such as clinical research, non-invasive cardiac testing, and as a supervisor of an endocrinology lab. Circumstances led Dr. Hilewitz to pursue a degree in Acupuncture, graduating 25 years ago, which she taught and practiced intensively for 10 years. She then went on to study naturopathic medicine graduating with a Naturopathic Doctor degree from Southwest College of Naturopathic Medicine (SCNM). Dr Hilewitz is board certified in naturopathic oncology and is a member of several professional organizations, including the.....
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